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Tirzepatide must be refrigerated at 36 to 46 degrees Fahrenheit

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Missing doses or varying the time by several hours each day creates peaks and valleys in blood concentration that reduce overall effectiveness and can worsen side effects like nausea

Studied in relation to energy expenditure and fat metabolism

First-line treatment typically involves: Methotrexate the most commonly prescribed conventional synthetic DMARD Sulfasalazine or hydroxychloroquine alternative or combination options Leflunomide for patients who cannot tolerate methotrexate These medications are usually combined with short-term corticosteroids (such as prednisolone) to provide rapid symptom relief whilst DMARDs take effect, which can take several weeks to months