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178,179 Additionally, cAMP can activate Rap1 through EPAC (Exchange Protein directly Activated by cAMP), 180,181,182 which is involved in regulating insulin secretion
As a result, the clinical translation potential of ferroptosis-based interventions remains theoretical and cannot yet guide clinical trial design
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Also, metabolites of VPA -oxidation (including propionic derivatives and 4-en-VPA) inhibit the mitochondrial CPS I, which is the first enzyme necessary for ammonia elimination via the urea cycle in the liver [19, 24]
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