Across multiple drug classes, common patterns emerge: Corticosteroids accelerate protein breakdown and deplete calcium, vitamin D, magnesium, zinc, and vitamin Cnutrients required for bone strength, collagen synthesis, and immune repair Acetaminophen consumes glutathione, increasing oxidative stress and impairing cellular recovery NSAIDs interfere with iron, folate, and vitamin C absorption while disrupting prostaglandin-driven tissue healing Opioids suppress endocrine and immune signaling necessary for regeneration Individually, these effects may appear modest
This may include: BMI 30, or 27 with related conditions Documented attempts at calorie reduction Exercise or physical activity history Behavioral or lifestyle counseling These requirements do not need to be perfectbut they do need to be documented
Buse JB, Drucker DJ, Taylor K et al
If youre outside Northern Virginia, we partner with Purepell, which has providers across the U.S
Some providers explore combination approaches, such as adding metformin to semaglutide or combining metformin with tirzepatide for additional insulin-sensitizing effects