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Based on this evidence, it is recommended that long-term pharmacological management prioritize the optimization of treatment timing, formulation of personalized dosing regimens, and implementation of systematic efficacy monitoring and adverse reaction assessment protocols, to maximize therapeutic benefits while minimizing potential risks

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In mouse models, a high-fat diet (HFD) caused an increase in the ratio of Firmicutes to Bacteroidetes, triggering the release of pro-inflammatory cytokines such as IL-6, IFN-, IL-1 and TNF- resulting in signs of endotoxemia