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These changes exacerbate the inflammatory characteristics of diabetic wounds, which reduce the expression of angiogenesis-related Runx-2 mRNA, resulting in lower levels of growth factor release, particularly vascular endothelial growth factor (VEGF), which is crucial for angiogenesis and wound healing

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12 BPC-157 has demonstrated significant protective effects against various GI injuries, including those caused by NSAIDs, alcohol, and stress

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