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In addition, NRF2 is regulated by the cytoplasmic inhibitor Kelch-like ECH-associating protein 1 (KEAP1)

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The metabolite, 1-kestose is considered a fructo-oligosaccharide (i.e., a prebiotic compound), that cannot be hydrolyzed by the gastrointestinal track and is fermented by hydrolytic microbes in the gut 94,95