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However, this meta-analysis included only one RCT 43 and one case-control study 51 for GLP-1RAs (but not the more recent semaglutide) 41

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To address these gaps, future research should prioritize larger scale multicenter randomized controlled trials with standardized protocols, adequately powered biomarker-guided RCTs with harmonised clinical endpoints plus GSH/GSSG, MDA/TBARS, SOD/CAT/GPx panels, head-to-head monotherapy vs

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