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Long-term outcomes trials with several different DPP-4 inhibitors have been performed, and their results are worth examining in order to understand both the mechanisms of action as well as the appropriate place of this class of drugs in diabetes care

Similarly, Phlorizin, discovered in 1835, was the precursor for SGLT2 inhibitors, which were invented in 1996

This can be an advantage for those seeking a gentler introduction to peptide therapy or with sensitivities to injections

GIP is also implicated in nausea attenuation, which may be why GLP-1/GIP dual agonists like tirzepatide have a slightly better GI tolerability profile than pure GLP-1 agonists

What the label does contain is a Warnings and Precautions subsection 5.9, Acute Gallbladder Disease which is a different category of statement