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These mirror the safety profile seen with GLP-1 receptor agonists broadly and are expected given the mechanism of action

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However, as with any medical treatment, there can be side effects

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Michael Lincoff, MD (Cleveland Clinic, OH), and colleagues showed that treatment with semaglutide reduced the risk of major cardiovascular eventsa composite of CV death, nonfatal MI, and nonfatal strokein patients with obesity and a prior history of cardiovascular disease