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Participants are usually adults with obesity or significant metabolic disease, often with additional criteria such as insulin resistance or cardiovascular risk factors

Insulin-like growth factor increases blood flow to the kidneys and the glomerular filtration rate (GFR) by directly or indirectly interacting with the renin-angiotensin system (RAS)

Many patients do well long-term at 5 to 10 mg tirzepatide or 1.0 to 1.7 mg semaglutide

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Plan ahead if you are considering pregnancy: Discuss stopping anti-obesity medication with your prescriber before trying to conceive