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resolve with titration.[1][43] Absolute Contraindications : History of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2.[3][44] Relative Contraindications : Pancreatitis, severe GI disease, pregnancy/breastfeeding.[1][45] Monitoring Parameters : HbA1c, lipids, liver enzymes, renal function every 3 months.[4][46] Regulatory Status FDA Classification : Investigational (Phase 3)

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Chronic Kidney Disease: If semaglutides kidney outcomes hold, nephrologists may join the fold, using GLP-1 RAs (in combination with SGLT2 inhibitors) to mitigate diabetic kidney disease progression