Pay in 4 interest-free payments of $6.02 Learn more
Ships within 48 hours · Estimated delivery Aug 8 - Aug 13
Details of the National Institutes of Health-funded study were published this week in a Nature paper titled A brain reward circuit inhibited by next-generation weight-loss drugs in mice. In it, the team reported that they investigated the small-molecule GLP-1s including Eli Lillys recently approved drug orforglipron, also known by the brand name Foundayo, as well as danuglipron, an oral GLP-1 that was being developed by Pfizer until the company decided to discontinue its development in 2025
It binds to GHRH receptors on pituitary somatotroph cells, stimulating the synthesis and secretion of endogenous growth hormone in a natural pulsatile pattern (1)
Mechanistically, an in vitro study found that exendin-4 inhibited the secretion of IL-1 and TNF- from mouse colonic smooth muscle cells (CSMCs) via the pathway mediated by cAMP and NF-B, thereby exerting anti-inflammatory effects [218]
10.1146/annurev.pharmtox.45.120403.100004
Josh is a wonderful PA who has clearly devoted his time and energy towards the hormone field
