The results: 35% reduction in body mass 30% decrease in adipocyte size 40% decrease in adipocyte volume No change in food intake (meaning the weight loss was purely metabolic) Cholesterol levels normalized to those of lean mice This is fundamentally different from appetite suppressants like GLP-1 agonists
LIFT-AD Trial: Phase 2/3 Termination (September 2024) Despite the ACT-AD disappointment, Athira advanced to a larger phase 2/3 trial called LIFT-AD
Vegan and plant-based diet Food Fact Sheet, British Dietetic Association
People looking for a body recomposition approach, where the goal is losing fat while preserving or building lean tissue, may benefit from the complementary mechanisms
In addition, the intricate nexus of signaling pathways controlling heavy metal stress tolerance in plants have been studied ( During heavy metal exposure, phytochelatins (PCs) are the most copious class of non-protein thiols (NPTs) synthesized utilizing both cysteine (Cys) and GSH (Nianiou-Obeidat et al., 2017)