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BGI (Yantian District, Shenzhen, China), an established contract research organization, isolated DNA from the remaining cecal samples and generated a metagenomic 16s rDNA amplicon library

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Studies in rodent models of NSAID-induced gut permeability demonstrated that BPC-157 administration prevented the permeability increase produced by indomethacin, preserving tight junction protein expression (ZO-1, occludin) at levels comparable to controls