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Ferrer M, Mourikis N, Davidson EE, Kleeman SO, Zaccaria M, Habel J, et al

For the SGLT2i cohort, we included patients who had received an SGLT2i for at least 6 months (Fig

(68), which reported that sweet taste receptor antagonism with lactisole reduced GLP-1 and PYY secretion but had no effect on CCK release, highlighting pathway-specific effects

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While current methods have transformed modern therapeutics, they remain constrained by poor oral bioavailability, stability challenges, cold-chain dependence, and limited patient acceptability associated with injectable administration, according to a review in AAPS PharmSciTech