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Updated March 5, 2026 Reviewed by Monica Vilhauer Ph.D

The Cochrane Database of Systematic Reviews , 2020 (4), CD013576

Genetic studies provided additional insights by delineating the epistatic interactions among these effector modules

Together, as MTHFR is an important enzyme for folate metabolism which plays critical role in epigenetic as DNA methylation, accumulated evidence showed that global DNA methylation can be associated with MTHFR polymorphism genotypes in both healthy populations and individuals with various diseases