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Mandalari G, Nueno-Palop C, Bisignano G, Wickham MS, Narbad A
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This participant was already taking tirzepatide when she enrolled in the trial, but before any stimulation was delivered, giving us a unique opportunity to make foundational observations about how the drug alters brain signals." At first, results were promising: As patient 3's tirzepatide levels reached full dosage, craving-linked NAc activity in her brain went dormant and she had no obsessive thoughts about food
Research suggests semaglutide may have enhanced ability to cross the blood-brain barrier compared to liraglutide, leading to stronger effects on the hypothalamic appetite centers
What is now needed are larger, prospective, randomized trials that can establish causality, characterize which women benefit most, identify the optimal timing and formulation of each therapy, and track outcomes across the full range of health domains this article has examined, metabolic, cardiovascular, cognitive, and functional
