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Risk Factors Metabolic syndrome (strongest risk factor) increased waist circumference (obesity) insulin resistance elevations in: blood sugar cholesterol triglycerides blood pressure uric acid Diabetes (up to 75% of individuals with type 2 diabetes have NAFLD) Sleep apnea Gut microbiome effects Genetic factors Why is it important to address
In addition, intranasal administration offers the potential advantages of a more rapid onset of action and avoidance of first-pass metabolism [28]
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Endocrinology 153 , 37353746 (2012)
Regional and cell-type differences are substantial, and observed changes may involve synthesis, transport, mitochondrial balance, or neuroinflammation (Aoyama, 2021)
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