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MACE (a composite of nonfatal MI, nonfatal stroke, and death from CV causes), assessed in a time-to-first-event analysis

Two more things from the data matter for before and after

Contact your healthcare provider promptly if you experience: Persistent dizziness lasting more than a few seconds when standing Fainting or near-fainting episodes Falls or loss of balance attributed to dizziness Chest pain, palpitations, or irregular heartbeat accompanying low blood pressure symptoms Severe or persistent nausea, vomiting, or diarrhea leading to dehydration Confusion, difficulty concentrating, or unusual fatigue Blood pressure readings consistently below 90/60 mmHg with symptoms New or worsening shortness of breath Seek emergency care (call 911) if you experience: Loss of consciousness Chest pain or pressure Severe shortness of breath Confusion or altered mental status Seizures Signs of stroke (facial drooping, arm weakness, speech difficulty) Your healthcare provider may need to adjust your GLP-1 medication dose, modify or discontinue antihypertensive medications, or investigate other potential causes of hypotension

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