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Particularly if someones got type 2 diabetes, they should be having once-a-year back-of-the-eye checks and understanding whether they might have additional risk factors, including their cup-to-disc ratio. According to the Database of Adverse Event Notifications, 36 cases of optic ischaemic neuropathy with GLP-1s have been identified, including 23 for semaglutide, 10 for tirzepatide and three for liraglutide

GLP-1R agonists present a promising therapeutic option for HFpEF by targeting endothelial dysfunction and other pathophysiological mechanisms

The question of whether novel disruption strategies have additional benefits has not been previously explored

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566 Gastrointestinal autonomic neuropathy Gastrointestinal autonomic neuropathy can affect any part of the gastrointestinal tract, leading to symptoms such as gastroparesis, constipation, and diarrhea