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GLP-1 medications do produce weight loss in clinical trials even without specific dietary intervention, but the results are consistently better when combined with improved diet and increased physical activity

doi: 10.1074/jbc.273.33.20737 31 LiYZhangCChenXYuJWangYYangYet al

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Research has identified 160 genes that are synergistically regulated by the combined action of IL-17 and TNF-alpha, meaning these two cytokines together produce effects far greater than either one alone