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choline an essential nutrient that supports liver function, contributes to the processing of chemical waste products, aids in fat metabolism, and distributes cholesterol to avoid its build-up in one part of the body

J Lab Hematol

In the liver, the 25-hydroxylase enzymes (CYP2R1 and CYP27A1) convert inactive cholecalciferol to 25(OH)VD 3 (calcidiol) by carbon 25 hydroxylation 14

Some practitioners use a twice-daily split (e.g., 250 mcg morning, 250 mcg post-workout) for injuries they consider higher grade

However, many endogenous and exogenous factors such as free radicals produced by chronic inflammation in the body, certain metabolites of cells and gut microbiota [14], as well as chemical carcinogens in the environment [15], ultraviolet (UV) radiation attack intracellular DNA and may cause a variety of DNA damage [3]