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[7] [8] GLP-1 plays a crucial role in glucose homeostasis by stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways

Liquid protein sources are often better tolerated than dense solid foods when gastrointestinal side effects are prominent

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A patients response may depend on: Starting weight Insulin resistance Appetite patterns Hormone changes Sleep quality Stress levels Muscle mass Nutrition habits Medication tolerance Dose progression Follow-up consistency Some patients begin comparing medications after a plateau, when semaglutide or tirzepatide results may slow over time and the treatment plan needs to be reassessed

CJB has also served on advisory boards, steering committees, safety monitoring boards and manuscript writing groups for clinical trials