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Most weight loss medications dont have a direct interaction with coffee, but stimulant-based ones like phentermine or Contrave can amplify caffeines effectsjitteriness, increased heart rate, and anxiety, Dr

They point to examples in which some users have already fallen ill from gray-market drugs

GLP-1 users face less hypoglycemia risk during exercise but may struggle with nausea if exercising too soon after injections

Both have potential for side effects, but if youre eligible for both medications, using them together is unlikely to add extra risk, says Lee

Preclinical investigations observed effects on adiponectin levels, hepatic lipid accumulation, and insulin sensitivity markers