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In experiments in rats with pilocarpine-induced status epilepticus, a reduction in the number and severity of chronic seizures was observed following treatment with celecoxib or parecoxib, COX2 inhibiting drugs (201, 202)

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Moreover, in recent in vivo mouse studies, supplementation with dietary choline led to elevated TMAO levels, thickened aortic valves, and valvular fibrosis 30,31

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