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Hepatic steatosis is associated with the alteration of nuclear receptors, membrane transport proteins and cellular enzymes [14,15]

GLP-1-related weight loss generally improves heat tolerance by reducing the thermal mass that needs to be cooled

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They help regulate blood sugar by: Increasing insulin secretion when blood glucose is high Reducing glucagon release Slowing gastric emptying Reducing appetite and caloric intake Originally developed for type 2 diabetes, these drugs also promote weight loss, leading to off-label use and new FDA approvals specifically for obesity management