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In studies on the specific dose of selenium needed to reduce thyroid antibodies, doses below 200 mcg did not help reduce thyroid antibodies, and doses greater than 900 mcg per day were found to be toxic

Patients who experience severe or prolonged nausea may develop food aversions that further compromise nutritional status

For everyday supplement use, though, the real comparison is between oral formats, and that's where bioavailability, how readily an ingredient is made available to the body, comes up

Feng L, Zhu C, Yuan H, Liu L, Lv F, Wang S (2013) Conjugated polymer nanoparticles: preparation, properties, functionalization and biological applications

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