week 4 semaglutide FDA approves obesity drug that helped people cut weight 15% Semaglutide results week by week:

Dual GLP-1/glucagon agonists such as survodutide have demonstrated substantial hepatic fat reduction and MASH improvement, though tolerability optimization may be needed

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Key findings at the highest dose (12mg weekly): Up to 24% mean body weight reduction over 48 weeks Significant reductions in fasting glucose and insulin resistance markers Meaningful reductions in liver fat content, relevant for participants with metabolic-associated fatty liver disease Once-weekly subcutaneous dosing was generally well-tolerated For context, semaglutide at its approved dose achieves approximately 1517% body weight reduction over 68 weeks