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The method's modular nature and lack of dependence on a training set make it attractive for exploring relative binding trends and guiding computational screening, yet it relies on several approximations, including incomplete treatment of conformational entropy and neglect of contributions from ordered binding-site water molecules [47, 48]

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Having a study population composed of over 90% of whites prevented ethnic heterogeneity from significantly affecting the investigation of the association between B12 deficiency and sepsis, albeit at the cost of limited insight into other ethnicities

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Gastrointestinal issues: Nausea or vomiting

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