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In 2005, the Federal Drug Administration approved Byetta, the first glucagon-like peptide-1 receptor agonist drug, to treat Type 2 diabetes

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Calcif Tissue Int 107:281293 Lv F, Cai X, Lin C, Yang W, Ji L (2024) Effects of semaglutide and tirzepatide on bone metabolism in type 2 diabetic mice

In HFD-fed KK-Ay mice, L-carnitine administration inhibited Srebp1c mRNA overexpression while increasing -hydroxybutyrate levels, suggesting concurrent lipogenesis suppression and -oxidation activation ( Hmgcr, Srebp2, Pcsk9, Ldlr ) in HFD-fed mice