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41 Conflicting results were found in larger studies on biopsy-confirmed NASH patients, where the same dose of sitagliptine (100 mg) given for 1 year improved NAS by ameliorating steatosis and ballooning, regardless of diabetic state, 42 and in another 24-week administration trial showed no superiority compared to placebo in reducing liver fat infiltration in prediabetic patients with NAFLD or those with diabetes mellitus and NAFLD

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Clinical research has evaluated cagrilintide for changes in body weight, energy intake, and metabolic parameters, often alongside lifestyle interventions

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