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The brain is constituted by a preponderance of microglia and astrocytes, these glial cells are essential in the Central Nervous System (CNS), with microglia functioning as innate immune cells involved in surveillance and defense, while astrocytes modulate neuronal communication, maintain the extracellular environment, and regulate inflammatory signaling (Garland et al., 2022) Both brain cells are able to produce pro- and anti-inflammatory cytokines (Schwarz and Bilbo, 2012)

As an inactive form, DRP-104 preferentially converts to DON within tumors [186]

The long noncoding RNA AATBC promotes breast cancer migration and invasion by interacting with YBX1 and activating the YAP1/Hippo signaling pathway

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Science 290 , 19721974 (2000)