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However, inhibition of PHGDH, when combined with carboplatin treatment, significantly reduced Ki67+ cells and increased CC3+ apoptotic cells

[2], [4] Retro-inverso peptides (also referred to as D-retro-inverso or DRI peptides) are specially engineered molecules in which the amino acid sequence is reversed and composed of D-amino acids, which are mirror images of the naturally occurring L-amino acids

A recent open label trial compared the efficacy of drugs currently used to lower ICP in IIH (amiloride, furosemide, spironolactone and topiramate) and found a marginal reduction in ICP with no difference between drugs [11]

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