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Compared with NPT1 wild type, I269T might have faster conformation changes leading to enhance renal urate export (Sakiyama et al., 2016)

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The GLP-1-reward field is, however, very young and much work remains to be done

5 In addition to the potential benefits of GLP-1 receptor agonists already mentioned, several dedicated cardiovascular outcome trials have reported positive cardiovascular and kidney outcomes with agents from the GLP-1 receptor agonist class