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One works from the top down through the brain

Wehr TA (1997)

Several animal studies and preliminary human trials have suggested that allulose may influence postprandial glucose responses and potentially affect GLP-1 secretion, though the evidence base remains limited and requires further validation

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DOI: 10.1016/j.clnu.2017.04.002, Takakura, K., Koda, N., Kinoshita, Y., et al