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10.1136/annrheumdis-2021-221795 26 RushJ

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Practice Guidelines: Superficial Venous Disease

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Hydration: Water keeps blood flowing and nutrients moving to healing tissues

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This multi-pathway approach - enhancing central access, synergizing at neuronal targets, and activating complementary energy expenditure pathways - provides a more robust physiological foundation than GLP-1 mono-agonism, justifying the stronger clinical evidence and the higher confidence in its substantial efficacy profile

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