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Instead of trying to develop things that people would crave, it shifts to food product guidance that is about tolerance, avoiding displeasures, or slowing down eating rates through textural design, Lundahl says

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For example, a patient may respond well to a low dose of phentermine but need a slightly higher dose of topiramate to manage cravings and evening eating patterns

Though some individuals knowingly combine or co-use opioids with stimulants or other depressants, an additional and growing concern is the adulteration of other drug supplies with fentanyl