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J Am Coll Cardiol 1995;26:1411-6

Methods Animals Sera were collected from 5 female Swiss albino mice and 5 female albino rats of age 6 weeks

12.5 and 15 mg: Maximum appetite suppression

The first is the antioxidant barrier: polyphenols establish antioxidant defense by activating the Nrf2 signaling pathway, and Nrf2 upregulates the expression of HO-1, SOD-1, NQO-1 and other oxidative genes, so as to increase the number of antioxidant enzymes (SOD/CAT/GPX/GSH), and to neutralize cisplatin-induced reactive oxygen species (ROS) and reactive nitrogen species (RNS)

Patients with a history of diabetic retinopathy should be monitored for worsening