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Additive effect on kidney outcomes including macroalbuminuria was also expected from AMPLITUDE-O substudy, however, additive effect of semaglutide and SGLT2i on the composite kidney outcomes without macroalbuminuria was not indicated in the FLOW substudy [50]

Both of these processes are mainly regulated by the signaling pathway: insulin-like growth factor-1 (IGF-1) phosphoinositide-3-kinase (PI3K) protein kinase B (Akt) mammalian target of rapamycin (mTOR)

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