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They should mainly be used as second-line therapy as add on to metformin in patients with type 2 diabetes who have no pre-existing cardiovascular disease and have a therapeutic goal to avoid hypoglycaemic events
Jill Carnahan The ritual
Low urinary pH predisposes for uric acid precipitation since the pKa of uric acid is 5.7, therefore the solubility of uric acid decreases with low pH, and thus increasing the risk of kidney stones (44)
By addressing both weight and blood sugar levels, tirzepatide offers a holistic approach to treatment that aligns with current trends in diabetes management, focusing on overall lifestyle improvement rather than merely symptom control
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