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Sept 21: In a setback for Intarcia Therapeutics, the FDAs Endocrinologic and Metabolic Drugs Advisory Committee voted unanimously that the benefits of its drug-device combination for Type 2 diabetes, ITCA 650, did not outweigh the risks

Additionally, the commercial product can be extremely expensive for consumers paying out of pocket. Name-brand GLP-1s pros and cons Pros FDA-approved More testing done Potential for health insurance coverage Cons More expensive Drug shortages Insurance approval can be difficult Compounded medication pros and cons Pros More readily available Less expensive The same ingredients as name-brand medication Compounders can customize the medication to the patients needs Cons No insurance coverage Not FDA approved There is no guarantee they are safe or effective Compounding medication may have additional benefits While compounded GLP-1s have the same ingredients as name-brand medication, Sam Tejada says that compounders can customize the medication to the patients needs: These compounded products also have the ability to be customized with other medications or different concentrations of the actual raw ingredients to fit the patient needs based off the personalized test results the doctor sees. Sam continues to explain that, Some of the compounders will include B12 or BPC-157 in the mixture with the GLP-1 medication because GLP-1s can potentially make food difficult to break down and digest

Retatrutide addresses this indirectly by reducing body fat, which is a major source of pro-inflammatory cytokines

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Studies comment that when the peptide was selected for further pharmacokinetic evaluation, it was found to be present in plasma beyond 72 h. [1] It may therefore exhibit improved pharmacokinetics compared to GHRH