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If you are concerned about any pain or discomfort, then a local numbing gel or ice pack can serve the purpose

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In vitro skin irritation test provides an alternative to animal testing and allows the screening of compounds before they undergo clinical testing

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K.McinnesG.et al (2015)

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Metformin , the first-line treatment for type 2 diabetes, is associated with reduced B12 levels in approximately 1030% of long-term users

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