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Ysa Barranco 5
The STEP-HFpEF trial randomised 529 patients with obesity (BMI 30 kg/m 2 ), HFpEF (left ventricular ejection fraction [LVEF] 45%) and New York Heart Association (NYHA) Class II symptoms to once-weekly subcutaneous semaglutide 2.4 mg or placebo
In this setting, glutathione depletion acts as a critical sensitizing factor that links intracellular redox-buffering capacity to tissue-level ferroptotic spread, effectively transforming stochastic cell death into coordinated population-level contagion
ShihCMChenYHLinYWTsaoNWWuSCKaoYTet al
We next explored the effect of combination treatment with TRAIL and BPTES, an inhibitor of glutaminase, a key enzyme in Gln metabolism, in vitro as well as in vivo in an orthotopic pancreatic tumor mouse model
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