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Some traditional antifungal drugs, such as itraconazole, voriconazole, and amphotericin B, have serious toxicities (Zavrel and White, 2015)

Cochrane Database Syst Rev (2016) (8):183

Varicose veins can also cause venous insufficiency, which is a true circulation problem that can occur in deeper veins and cause blood clots

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as a result, surfactant production decreases markedly, which in turn causes alveolar fluid accumulation leading to alveolar collapse and ARDS (Matthay and Zemans, 2011