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According to the MHRA SmPC and EMA EPAR for Wegovy, there is no signal that semaglutide directly worsens hiatal hernia or causes structural changes to the oesophageal hiatus

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These drugs include GLP-1R agonists like Semaglutide, Liraglutide, Dulaglutide, and PEG-Loxenatide, and the GIPR/GLP-1R dual agonist Tirzepatide

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