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Excess adipose tissue produces estrogen through aromatization of androgens, disrupting the hypothalamic-pituitary-gonadal axis

Medications can help but work best combined with weight management

So when you add that effect together with semaglutide that suppresses appetite, you get the synergistic effect where you get primarily loss in body fat and very little, if any, loss in lean mass

Patients should also report any side effects they experience , particularly severe, persistent abdominal pain (with or without vomiting) which could suggest pancreatitis or gallbladder disease and requires urgent medical review

Monthly evaluations by your provider ensure that you experience steady, controlled weight loss