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2018), regulate the intracellular redox state, and stimulate the expression of anti-oxidative enzymes in cells (Wu et al
Tirzepatide is a dual GIP/GLP-1 receptor agonist, while semaglutide only targets GLP-1
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In cell and animal models, amino acid metabolism not only provides substrates for energy production and biosynthesis, but also regulates the differentiation of macrophages toward M1 or M2 phenotypes by modulating signaling pathways such as STAT1, mechanistic target of rapamycin (mTOR), and NF-B, as well as by affecting epigenetic regulation (59)
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