Clinical trials would need an IND protocol
This study which investigated the impact of abrogating the DPP4 enzyme activity (i.e., by utilizing DPP4 mutant rat or Sita) on protecting the brain and the corresponding functional integrity against the AHS yielded several preclinical striking implications
Preclinical studies in diet-induced-obese mice had shown no toxicity or adverse reaction at doses five times higher than those required to effect weight loss
Here we demonstrated that the opposite is also true: extracellular GSH is a precursor to intracellular cysteine
Phytother Res 38(4):17351744 Gao W, Gao S, Zhang Y, Wang M, Liu Y, Li T, Gao C, Zhou Y, Bian B, Wang H (2024b) Altered metabolic profiles and targets relevant to the protective effect of acteoside on diabetic nephropathy in db/db mice based on metabolomics and network pharmacology studies