Support fat metabolism , helping to maintain a lean body composition
In recent years, GLP-1 medications have transformed the conversation around obesity and weight management
These may include nausea, decreased appetite (which can help with weight loss), and minor digestive changes
In yeast, Ohsumis and Klionskys laboratories first identified that ATG32 acts as the mitophagy-specific receptor, which directly interacts with the selective autophagy adaptor ATG8 via an ATG8-interacting motif (AIM) and ATG11 to form the nascent autophagosome (Okamoto et al., 2009)
However, apomorphines efficacy was modest, and it tended to cause a lot of nausea (because it stimulates dopamine receptors indiscriminately, including in the chemoreceptor trigger zone)