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Crucially, FOXO4-DRI selectively induced apoptosis in senescent TM3 Leydig cells by causing nuclear exclusion of active Ser15-phospho-p53, leading to a significant increase in apoptosis rate and altering pro-apoptotic (BAX, cleaved-Caspase3 increase) and anti-apoptotic (BCL-2 decrease) protein levels
CuiMHongYHuangJLiuKChenJTanYet al
It soon became a bustling frontier town with storefronts along Clematis and Narcissus streets, and saloons lining Banyan Street
Given that more than 7500 genetic disorders and 290,000 disease-causing mutations are cataloged in the OMIM and HGMD databases, it is not feasible to develop clinical-grade vectors for each specific mutation
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